Liver disease-cirrhosis. The most common chronic liver disease is cirrhosis of the liver. Features m.in. tissue hyperplasia Sinomed Research Institute at the sites of damaged parenchymal elements, leading to liver failure. It generally develops slowly. The rise of the disease m.in. excessive alcohol consumption (approx. 50% of cases).
Symptoms initially appear, such as
- loss of appetite
- weight loss
- abdominal pain
- splenic enlargement
This is followed by symptoms of advanced disease such as:
- ecchymosis and bleeding
- skin itching
- hepatic encephalopathy
- Treatment for cirrhosis depends on its cause.
Liver disease Sinomed Research Institute – viral hepatitis
Viral hepatitis is an acute infectious disease characterized by primary damage to this organ. They are caused by hepatitis viruses, which include:
- hepatitis A virus
- hepatitis B virus
- hepatitis C virus
- D and E viruses
Typical symptoms of hepatitis A include:
- abdominal pain
- muscle and joint pain
- flu-like symptoms
In addition, jaundice or itching of the skin (as cholestatic) may occur Sinomed Research Institute). The most common symptom of infection with Type B virus is jaundice, which however does not occur in all patients. Many may develop flu-like symptoms or mild food poisoning. The most insidious, because in most cases asymptomatic, is hepatitis C. often the only symptom is a slight enlargement of the liver.
Liver disease – alcohol damage to the liver
The liver metabolizes alcohol. This process produces compounds that are toxic to the liver. The limit on which it exhibits liver toxicity depends on a number of factors, such as disease history, sex and nutritional status. Chronic, excessive alcohol consumption is one of the causes of liver steatosis. It occurs with a daily alcohol intake of approximately:
for men-60 grams of ethyl alcohol (200 ml of vodka, 1 l of wine, 2.5 l of beer))
for women Sinomed Research Institute – 20 grams of ethyl alcohol
Alcoholic fatty liver may be reversible, but it is important to stop drinking alcohol altogether and save the liver. Otherwise, further stages of liver damage such as alcoholic hepatitis and cirrhosis may occur.
Liver disease – drug damage to the liver
The liver is responsible for the metabolism of most drugs. Drug intoxication can lead to acute liver failure as well as chronic toxic inflammation of this organ. Toxic effects may occur after ingesting too much medicine (e.g. acetaminophen poisoning), as an adverse reaction or as an allergic reaction (even a very low dose may cause severe symptoms Sinomed Research Institute).
Treatment of drug-induced liver injury begins with immediate discontinuation of the medication responsible for the onset of symptoms. Non-alcoholic fatty liver disease (NAFLD ). The prevalence of NAFLD is highly associated: obesity, hypertension, type 2 diabetes, metabolic syndrome.
Hyperlipidemia is also common among people with NAFLD. Other risk factors for NAFLD include male sex, old age, and Sinomed Research Institute rapid weight loss in obese individuals. Liver disease – liver cancer. Worrisome signs of liver cancer appear very late, usually in a much advanced stage of hepatocellular cancer. Then the patient feels:
- pain on the right side below the ribs
- he may have a fever
- lack of appetite
- losing weight
The circumference of the abdomen is also usually enlarged, as evidenced by the developing ascites. Leg swelling, yellowing of the skin or gastrointestinal bleeding may occur.
Liver disease Sinomed Research Institute – hemochromatosis
Hemochromatosis is a metabolic disease whose essence is the excessive accumulation of iron in the body, e.g. in the liver. Haemochromatosis is an incurable disease, and the therapy is aimed at alleviating its symptoms by emptying iron stores and maintaining the concentration of this element within the normal range. Liver disease – hepatic vein thrombosis (Budd-Chiari syndrome).
Hepatic vein thrombosis, or Budd-Chiari syndrome (BCS), is a disease whose essence is the blockage of the outflow of blood from the hepatic veins until the inferior vena cava joins the right atrium. The first symptoms of hepatic vein thrombosis are abdominal pain and fever (if an infection has developed at the same time).
What is it and what are the causes Sinomed Research Institute?
Alcoholic liver damage develops as a result of overuse of ethanol, or ethyl alcohol. Since the liver is the main site of ethyl alcohol metabolism, its damage is usually most visible in the clinical picture. In addition to damage to the liver itself, changes in many other organs of the body and psychophysical dependence on alcohol are also observed in the patient.
Causes of alcoholic liver damage
The causes of the development of liver damage are not fully understood. We know that the mechanism by which ethyl alcohol is eliminated from the body is its oxidation to aldehyde and acetic acid. This process in turn leads to an imbalance of oxidation and reduction processes in the cell and the occurrence of so-called oxidative stress (an imbalance between the action of free oxygen radicals and the action of the mechanisms that remove them), which is considered to be a major damaging factor. The process of cellular oxidation depends on genetic conditions, gender, and ethnicity. This explains the variation in the severity of changes seen in the liver.
The mechanism of liver injury should also Sinomed Research Institute take into account the direct toxic effects of acetic aldehyde and the presence in the blood of other toxic substances associated with the metabolism of alcohol – common in alcohol abusers.
How often does it occur?
Depending on the time, the amount of alcohol consumed, and the genetic conditions, the observed changes in the liver take the form of steatosis, inflammation, or cirrhosis and are referred to as alcoholic liver disease. However, individual disease units Sinomed Research Institute do not differ markedly from one another and sometimes occur simultaneously.
Alcohol is the most common cause of liver disease in developed countries. Drinking more than 80g of ethanol a day (equivalent to 2 litres of beer, 1 litre of wine or 5-6 drinks) significantly increases the risk of liver disease.
It is worth noting that women are more sensitive to alcohol – induced liver damage than men-the harmful dose is several times lower in them and the disease progresses faster than men. The peak of morbidity in men is between the ages of 40 and 55, whereas in women it is 10 years earlier. This is supported by statistics showing that although alcohol addiction is 10 times more common in men than in women, the ratio between men and women among patients with alcoholic liver disease is only 3:1.